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  • Title: Extracellular water/intracellular water is a strong predictor of patient survival in incident peritoneal dialysis patients.
    Author: Chen W, Guo LJ, Wang T.
    Journal: Blood Purif; 2007; 25(3):260-6. PubMed ID: 17429200.
    Abstract:
    BACKGROUND: The mortality rate of peritoneal dialysis (PD) patients is still high and controversies persist regarding the mortality predictor. This study was designed to identify the predictability of the extracellular water/intracellular water ratio (E/I) on mortality in PD patients. METHODS: 227 incident PD patients were included. Time-dependent Cox proportional hazard regression was used to investigate the predictability of E/I on mortality. RESULTS: The 2- and 3-year survival was 74 and 65%, respectively. Univariate Cox proportional hazard regression analysis showed that the significant predictors of mortality were age, sex, Charlson Comorbidity Index, total Kt/V, serum albumin, pulse pressure, presence of malnutrition, and E/I. However, the final Cox proportional hazard models revealed that E/I was the only significant predictor. For every increase of 0.1 in the E/I value, the relative risk of death was 1.368. CONCLUSIONS: E/I is a strong independent predictor of mortality in incident PD patients.
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