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  • Title: [Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid].
    Author: Tao JN, Duan SM, Li J.
    Journal: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 2007 Mar; 21(1):79-82. PubMed ID: 17429545.
    Abstract:
    OBJECTIVE: To investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA). METHODS: Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT. RESULTS: The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related. CONCLUSION: ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.
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