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  • Title: In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
    Author: Philippe G, De Mol P, Angenot L, Tits M, Frédérich M.
    Journal: Planta Med; 2007 May; 73(5):478-9. PubMed ID: 17431825.
    Abstract:
    Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
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