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  • Title: 1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site.
    Author: Neri P, Meadows R, Gemmecker G, Olejniczak E, Nettesheim D, Logan T, Simmer R, Helfrich R, Holzman T, Severin J.
    Journal: FEBS Lett; 1991 Dec 02; 294(1-2):81-8. PubMed ID: 1743298.
    Abstract:
    The backbone 1H, 13C and 15N chemical shifts of cyclophilin (CyP) when bound to cyclosporin A (CsA) have been assigned from heteronuclear two- and three-dimensional NMR experiments involving selectively 15N- and uniformly 15N- and 15N,13C-labeled cyclophilin. From an analysis of the 1H and 15N chemical shifts of CyP that change upon binding to CsA and from CyP/CsA NOEs, we have determined the regions of cyclophilin involved in binding to CsA.
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