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  • Title: The use of a single pulse of intravenous methylprednisolone in the treatment of corneal graft rejection. A preliminary report.
    Author: Hill JC, Maske R, Watson PG.
    Journal: Eye (Lond); 1991; 5 ( Pt 4)():420-4. PubMed ID: 1743357.
    Abstract:
    In corneal graft rejection, rapid reversal of the rejection process is necessary to minimise endothelial cell loss. Ten consecutive patients with acute endothelial rejection were treated with a single 500 mg pulse of methylprednisolone intravenously and topical prednisolone 1% drops hourly. The rejection episode was successfully reversed in eight (80%) of the 10 grafts. This preliminary trial indicates that cortico-steroid pulse therapy may be beneficial in the management of severe corneal graft rejection with the advantage of avoiding prolonged oral corticosteroid therapy.
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