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  • Title: Nucleolar organizer regions argyrophilic associated proteins in cutaneous melanocytic lesions.
    Author: Reis JP, Tellechea O, Baptista AP.
    Journal: Dermatologica; 1991; 183(2):136-8. PubMed ID: 1743375.
    Abstract:
    We applied a simple silver staining technique to visualize nucleolar organizer regions associated proteins (AgNORs) for the study of 47 melanocytic lesions (20 malignant melanomas, 5 dysplastic nevi, 4 Spitz nevi, 2 Reed and Gartman's fusiform nevi and 16 melanocytic nevi). A statistically significant difference existed between the numbers of AgNORs per cell in benign and malignant lesions as a group. However, some overlapping counts were found, limiting the usefulness of the technique in differentiating benign from malignant lesions in individual cases.
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