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  • Title: A split zinc-finger protein is required for normal yeast growth.
    Author: Blumberg H, Silver P.
    Journal: Gene; 1991 Oct 30; 107(1):101-10. PubMed ID: 1743508.
    Abstract:
    We have identified a gene that, when present in multiple copies, partially inhibits nuclear protein localization in Saccharomyces cerevisiae. This gene encodes a protein that is a unique member of the Cys2His2 zinc-finger family of DNA-binding proteins. It is designated SFP1 for split finger protein because its two zinc-finger domains are separated from one another by 40 amino acids (aa) as opposed to the usual spacing of 7 or 8 aa for Cys2His2 proteins. Disruption of the SFP1 gene results in slow cell growth, with cells having multiple, nucleated buds.
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