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  • Title: [Antineutrophil cytoplasmic antibody (Anca)-associated autoimmune disease induced by propylthiouracil].
    Author: Pietszkowski NC, Carvalho GA, Souza HN, Werka CR, Borazo LA, Graf H, Carvalho Md.
    Journal: Arq Bras Endocrinol Metabol; 2007 Feb; 51(1):136-41. PubMed ID: 17435868.
    Abstract:
    Antithyroid drugs sometimes cause severe complications. Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO). Our objective is to describe a female patient with Graves' disease, who developed PTU induced-autoimmune disease, with cutaneous, pulmonary, and renal lesions, associated with ANCA. Histopathological examination revealed diffuse pulmonary hemorrhage, and focal segmental glomerulosclerosis at the kidney biopsy. She was treated with systemic corticosteroid therapy and cyclophosphamide, with clinical improvement. This case highlights the need for greater awareness of this relatively rare adverse effect of propylthiouracil.
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