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  • Title: Disseminated histiocytosis with undetermined Langerhans' cells simulating an acute non lymphoid leukemia.
    Author: Miano C, Bosman C, Boldrini R, DonFrancesco A, Ceci A, Mancini S, Rosati D.
    Journal: Haematologica; 1991; 76(3):240-2. PubMed ID: 1743596.
    Abstract:
    The authors report on a case of disseminated Langerhans' cell histiocytosis with a clinical presentation and a bone marrow simulating, at onset, an acute leukemia non lymphoid. A hepatic needle biopsy performed for the progressive enlargement of the liver oriented the diagnosis towards a Langerhans' cell histiocytosis. The morphological, immunohistochemical and ultrastructural study of these cells showed them to be undetermined, i.e. Langerhans' cell precursors.
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