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  • Title: Hepatic prolyl hydroxylase activity in experimental cirrhosis.
    Author: McPhie JL, Short LT.
    Journal: Acta Hepatogastroenterol (Stuttg); 1975 Dec; 22(6):387-91. PubMed ID: 174370.
    Abstract:
    Hepatic collagen synthesis was studied during progressive fibrosis induced by carbon tetrachloride in male Sprague-Dawley rats by determination of prolyl hydroxylase activity and hydrocyproline levels along with morphological assessment of fibrosis. Cirrhosis was present after approximately 4 weeks treatment. Prolyl hydroxylase activity was increased significantly before fibrosis was apparent histologically or by hydroxyproline levels. The significance of this finding is discussed.
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