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  • Title: Immunogenicity study of abbreviated rabies preexposure vaccination schedules.
    Author: Khawplod P, Wilde H, Benjavongkulchai M, Sriaroon C, Chomchey P.
    Journal: J Travel Med; 2007; 14(3):173-6. PubMed ID: 17437473.
    Abstract:
    OBJECTIVE: To evaluate abbreviated preexposure rabies vaccination schedules that would reduce cost and shorten time required for completion. METHOD: A random prospective immunogenicity study, using a group of 96 volunteer preclinical veterinary students, primary school children, and hospital-based health care workers. They were divided into six groups and administered abbreviated schedules of preexposure tissue culture rabies vaccines. Neutralizing antibodies were determined on days 0 and 360, and following boosters on days 367 and 374. RESULTS: All subjects, including one group that received only 0.1 mL intradermally at two sites on one day, had detectable neutralizing antibody titers 1 year later and responded with an accelerated antibody response when given booster injections. CONCLUSION: It might be possible to develop a 1-week and even one clinic visit preexposure vaccine schedule that would provide at least 1 year of immune memory.
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