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  • Title: PLK1 inhibitors: setting the mitotic death trap.
    Author: Plyte S, Musacchio A.
    Journal: Curr Biol; 2007 Apr 17; 17(8):R280-3. PubMed ID: 17437704.
    Abstract:
    Polo-like kinase 1 (Plk1) regulates mitotic progression in all eukaryotes and has been implicated in the transformation of human cells. Analysis of the cytological and anti-tumor activities of BI 2536, a novel, selective pharmacological inhibitor of Plk1, has connected chemistry and biology to the bedside.
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