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  • Title: Highly enantioselective alpha-aminoxylation of aldehydes and ketones with a polymer-supported organocatalyst.
    Author: Font D, Bastero A, Sayalero S, Jimeno C, Pericàs MA.
    Journal: Org Lett; 2007 May 10; 9(10):1943-6. PubMed ID: 17439136.
    Abstract:
    The first catalytic enantioselective alpha-aminoxylation of aldehydes and ketones using an insoluble, polymer-supported organocatalyst (1) derived from trans-4-hydroxyproline is reported (ee: 96-99%). Reaction rates in the aminoxylation of cyclic ketones with 1 are higher than those reported with l-proline. The insoluble nature of 1 simplifies workup conditions and allows catalyst recycling without an apparent decrease in enantioselectivity or yield.
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