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  • Title: Profile of cytokine gene polymorphisms in Iranian multiple sclerosis patients.
    Author: Amirzargar A, Khosravi F, Dianat S, Hushmand F, Maryousef P, Foroushani AR, Lotfi J, Nikbin B.
    Journal: Mult Scler; 2007 Mar; 13(2):253-5. PubMed ID: 17439892.
    Abstract:
    BACKGROUND: Cytokine gene polymorphisms have been extensively studied in association with different diseases. The role of cytokine gene polymorphisms in multiple sclerosis (MS), as a chronic immune-mediated neurodegenerative disease, has been previously reported. MATERIALS AND METHODS: DNA samples were collected from 44 patients with relapsing-remitting multiple sclerosis (RRMS) and 140 unrelated healthy subjects. All participants in this study were matched for ethnicity. Cytokine gene SNPs were determined using the PCR-SSP method. RESULTS: and discussion We found no significant differences between MS patients and controls in most of the studied cytokine genes. Remarkable results were obtained for IL-2 GG-330 genotype (P =0.06), IL-6 C-174 allele (P =0.06), CG and GG genotypes (P <0.001), and GG (P =0.02) and CG (P <0.001) haplotypes, and TNF-alpha A-238 allele (P <0.001), GG (P =0.003) and GA (P <0.001) haplotypes. These results suggest that polymorphic variations of these pro-inflammatory cytokines play an important role in susceptibility to MS.
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