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  • Title: Sulfasalazine-induced pericarditis in a patient with ulcerative colitis without recurrence when switching to mesalazine.
    Author: Perrot S, Aslangul E, Szwebel T, Gadhoum H, Romnicianu S, Le Jeunne C.
    Journal: Int J Colorectal Dis; 2007 Sep; 22(9):1119-21. PubMed ID: 17440739.
    Abstract:
    INTRODUCTION: Pericarditis is rarely reported in inflammatory bowel disease. Besides its common causes, pericarditis could be related to ulcerative colitis flare or to 5-aminosalicylic acid (5-ASA) treatment. CASE REPORT: We report the case of a patient in whom fever, weight loss and pericarditis developed after 16 years of treatment with sulfasalazine for ulcerative colitis, after increasing the daily dosage from 1 to 3 g. DISCUSSION: The patient recovered after treatment discontinuation and did not exhibit any recurrence of pericarditis when treatment with mesalazine was introduced. CONCLUSION: In conclusion, if pericarditis occurs in ulcerative colitis patients treated with 5-ASA compounds, the treatment should be considered as a possible cause, even after an increase of the dosage. In this case, discontinuation of the treatment and cautious switch to another 5-ASA compound should be tested.
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