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  • Title: Synthesis and antimalarial property of orally active phenoxazinium salts.
    Author: Takasu K, Shimogama T, Satoh C, Kaiser M, Brun R, Ihara M.
    Journal: J Med Chem; 2007 May 17; 50(10):2281-4. PubMed ID: 17441706.
    Abstract:
    Phenoxazinium salts were found to display good antimalarial efficacy in vivo against Plasmodium berghei. Several compounds provided 100% parasitemia clearance at a dose of 20-30 mg kg-1x4 days (ip) and good survival effects without obvious acute toxicity. They also showed excellent potency by oral administration. A preliminary pharmacokinetic study revealed that the oral availability of 1a was excellent.
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