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  • Title: Birth after intracytoplasmic sperm injection with use of testicular sperm from men with Kartagener or immotile cilia syndrome.
    Author: Kaushal M, Baxi A.
    Journal: Fertil Steril; 2007 Aug; 88(2):497.e9-11. PubMed ID: 17442314.
    Abstract:
    OBJECTIVE: To describe a case of intracytoplasmic sperm injection (ICSI) with testicular sperm in men with immotile cilia syndrome and to discuss the role of micromanipulation in the treatment of these patients. DESIGN: Case report. SETTING: Private infertility clinic and assisted reproduction unit. PATIENT(S): Couple with male factor infertility due to Kartagener's/immotile cilia syndrome. INTERVENTION(S): The patient's partner underwent ICSI with testicular sperm. MAIN OUTCOME MEASURE(S): Semen characteristics, sperm viability, fertilization and cleavage rate, pregnancy, and birth after ICSI. RESULT(S): With testicular sperm, the two pronuclear fertilization rates were 53%. ICSI was successful in the first cycle. The uncomplicated pregnancy resulted in the birth of two healthy children, male/female twins. CONCLUSION(S): With testicular sperm, successful oocyte fertilization after ICSI in couples with male Kartagener or immotile cilia syndrome is possible with nonprogressive motile sperm resulting in clinically healthy offsprings.
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