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  • Title: Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents.
    Author: Ferreira SB, Costa MS, Boechat N, Bezerra RJ, Genestra MS, Canto-Cavalheiro MM, Kover WB, Ferreira VF.
    Journal: Eur J Med Chem; 2007; 42(11-12):1388-95. PubMed ID: 17445951.
    Abstract:
    Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Our results show that the introduction of the difluoromethylene moieties has turned the inactive carbaldehydes into active antileishmanial compounds.
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