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  • Title: Bispolides, novel 20-membered ring macrodiolide antibiotics from microbispora.
    Author: Okujo N, Iinuma H, George A, Eim KS, Li TL, Ting NS, Jye TC, Hotta K, Hatsu M, Fukagawa Y, Shibahara S, Numata K, Kondo S.
    Journal: J Antibiot (Tokyo); 2007 Mar; 60(3):216-9. PubMed ID: 17446696.
    Abstract:
    Seven new related compounds named bispolides A1, A2, A3, B1, B2a, B2b and B3, have been found in a culture of Microbispora sp. A34030, isolated from a Malaysian soil sample. The planar structures were elucidated to be new 20-membered ring macrodiolide antibiotics on the basis of MS and NMR spectroscopic analyses. These antibiotics showed a good anti-MRSA activity in vitro.
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