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  • Title: Endoscopic pyloroplasty with full-thickness transgastric and transduodenal myotomy with sutured closure.
    Author: Park PO, Bergström M, Ikeda K, Fritscher-Ravens A, Mosse S, Kochman M, Swain P.
    Journal: Gastrointest Endosc; 2007 Jul; 66(1):116-20. PubMed ID: 17451701.
    Abstract:
    BACKGROUND: Pyloroplasty with myotomy and sutured closure is a surgical treatment for gastric outlet obstruction. It has not been previously performed at flexible endoscopy. OBJECTIVE: To develop and test a method for performing a sutured pyloroplasty at flexible endoscopy. DESIGN: A Heinicke-Miculicz pyloroplasty was performed, forming a linear myotomy through the pylorus from the gastric side into the duodenal bulb. This was subsequently sutured transversely to increase the opening. The operation was performed in 3 nonsurvival studies in pigs. The safety and the efficacy was then studied in 7 animals followed for up to 4 weeks after the procedure. SETTING: The studies were performed in experimental surgical units in Gothenburg, Sweden, and London, UK. INTERVENTIONS: A linear needle-knife incision was made through the pylorus; full-thickness sutures, by using a new T-tag and polypropylene thread suturing system through a flexible gastroscope, were placed to close the incision transversely. In 2 pigs, the prepyloric bulge was excised before the pyloroplasty. RESULTS: Pyloroplasty was readily accomplished at flexible endoscopy in the 3 nonsurvival studies. Six of 7 pigs that survived in this study for periods of 7 to 28 days, recovered well, without complications. One pig (with bulge removal) developed gastric retention. The pyloric opening was increased; it was then easy to enter the duodenum at follow-up endoscopy. LIMITATIONS: This method has yet to be studied clinically. CONCLUSIONS: Pyloroplasty with full-thickness pyloromyotomy and transverse closure of a linear myotomy was accomplished by using a simple flexible endosurgical technique to test a new flexible suturing system.
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