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  • Title: Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?
    Author: Schwarz M, Andrade-Navarro MA, Gross A.
    Journal: Apoptosis; 2007 May; 12(5):869-76. PubMed ID: 17453157.
    Abstract:
    Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.
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