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  • Title: HTLV-I-associated myelopathy: clinicopathologic correlation with localization of provirus to spinal cord.
    Author: Bhigjee AI, Wiley CA, Wachsman W, Amenomori T, Pirie D, Bill PL, Windsor I.
    Journal: Neurology; 1991 Dec; 41(12):1990-2. PubMed ID: 1745362.
    Abstract:
    A 49-year-old South African man developed a rapidly progressive myelopathy 14 months after blood transfusion and died 1 year after the onset of symptoms. Detailed pathologic examination of the spinal cord was consistent with the diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although no HTLV-I viral particles, antigens, or nucleic acids were detected in situ, polymerase chain reaction assays revealed HTLV-I proviral DNA in cervical, thoracic, and lumbar levels of the spinal cord, with the greatest amount being detected at the thoracic level. These findings suggest that the pathogenesis of HAM/TSP depends on direct infection of neural or immune elements within the spinal cord.
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