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  • Title: [The heart, the elderly, and diabetes mellitus. Epidemiologic study of 333 ambulatory clinical cases].
    Author: Tamburrini LR, Di Monte M, Ponte E, Vriz O.
    Journal: Minerva Med; 1991 Oct; 82(10):665-73. PubMed ID: 1745377.
    Abstract:
    The paper proposes a new classification to describe the normal senile heart and its pathological forms: "small aortic heart" (nonhypertrophic-dilatative myocardiopathy and its ischemic form) and "large aortic heart" (hypertrophic-dilatative myocardiopathy and its ischemic form). The statistical distribution of 241 elderly patients with diabetes mellitus using this classification was compared to a control group of 92 elderly non-diabetic subjects. The results reveal the significant epidemiological incidence of ischemic cardiopathy with small aortic heart in diabetic patients compared to the control group in which more ischemic hypertrophic-dilatative cardiopathies were present. This observation supports the hypothesis that senile diabetic cardiopathy begins with a metabolic block with reduced contractile energy, and the overlying important ischemic component leads to the development of the small-size clinical phenotype.
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