These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Interaction of the protein C activation peptide with platelets.
    Author: Martínez-Cruz R, Canseco Mdel S, Lopez-Martínez J, Cruz PA, Pérez-Campos E, Cruz MM, Alva FC, Majluf-Cruz A, Zenteno E, Ruiz-Argüelles A.
    Journal: Prep Biochem Biotechnol; 2007; 37(2):139-47. PubMed ID: 17454824.
    Abstract:
    The peptide NH(2)-DTEDQEDQVDPR-COOH is released during activation of protein C zymogen. We measured the effect of a synthetic peptide with an amino acid sequence similar to that of the natural peptide on platelets from healthy individuals using platelet aggregometry. We found that this synthetic peptide inhibits platelet aggregation induced by thrombin; furthermore, it diminishes mobilization of intraplatelet calcium. Molecular docking showed weak interaction between the synthetic peptide and thrombin. Our findings suggest that this synthetic peptide may interact with a receptor located on the platelet cell membrane.
    [Abstract] [Full Text] [Related] [New Search]