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  • Title: [Genetic effects of workers occupationally exposed to mercury using three genetic end-points].
    Author: Guo WJ, Zhao XY, Li SY, Chen CH, Chen ZJ, Lou JL, Zheng W, Deng HP.
    Journal: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2007 Feb; 25(2):84-6. PubMed ID: 17456398.
    Abstract:
    OBJECTIVE: To investigating genetic effects of workers occupationally exposed to mercury (Hg). METHODS: The peripheral lymphocytes from 20 workers exposed to mercury and 20 controls were measured with micronucleus test, comet assay, hrpt gene mutation test and TCR gene mutation test. RESULTS: The mean micronuclei rate(MNR) and mean micronucleated cells rate(MCR) in 20 workers were (5.90 +/- 0.91) per thousand and (5.30 +/- 0.81) per thousand, respectively while MNR and MCR in controls were (1.50 +/- 0.47) per thousand and (1.30 +/- 0.31) per thousand respectively, The difference of MNR and MCR between workers and controls was very significant (P < 0.01). The mean tail length (MTL) of workers and controls were (3.16 +/- 0.31) and (0.99 +/- 0.07) microm, respectively. The mean tail moment (MTM) of workers and controls were 1.63 +/- 0.22 and 0.39 +/- 0.03, respectively, There was a significant difference in MTL and MTM between workers and controls(P < 0.01). When the average mutation frequencies (Mfs-hprt) of hprt and (Mfs-TCR) of TCR of workers were compared with those of controls, there were not significant difference (P > 0.05). CONCLUSION: The results of the investigation indicated that the adverse genetic effects in workers occupationally exposed to mercury could be detected.
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