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Title: Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871. Author: Graf E, Schneider K, Nicholson G, Ströbele M, Jones AL, Goodfellow M, Beil W, Süssmuth RD, Fiedler HP. Journal: J Antibiot (Tokyo); 2007 Apr; 60(4):277-84. PubMed ID: 17456980. Abstract: Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.[Abstract] [Full Text] [Related] [New Search]