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  • Title: Using aptamers to identify and enter cells.
    Author: Chu T, Ebright J, Ellington AD.
    Journal: Curr Opin Mol Ther; 2007 Apr; 9(2):137-44. PubMed ID: 17458167.
    Abstract:
    While nucleic acid binding species (aptamers) have previously been selected against a variety of biomedically important protein targets, the selection of aptamers against complex targets, such as cell surfaces and organisms, is becoming increasingly feasible. A number of aptamers have now been generated that can target specific cell-surface antigens and cell types, including tumor biomarkers and tumor cells. The generation of anti-cell aptamers has important implications for identifying disease-specific biomarkers, generating diagnostics, and developing novel drug delivery strategies.
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