These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system.
    Author: Krauland AH, Alonso MJ.
    Journal: Int J Pharm; 2007 Aug 01; 340(1-2):134-42. PubMed ID: 17459620.
    Abstract:
    The aim of this study was to generate a new type of nanoparticles made of chitosan (CS) and carboxymethyl-beta-cyclodextrin (CM-beta-CD) and to evaluate their potential for the association and delivery of macromolecular drugs. CS and CM-beta-CD or mixtures of CM-beta-CD/tripolyphosphate (TPP) were processed to nanoparticles via the ionotropic gelation technique. The resulting nanoparticles were in the size range of 231-383 nm and showed a positive zeta potential ranging from +20.6 to +39.7 mV. These nanoparticles were stable in simulated intestinal fluid pH 6.8 at 37 degrees C for at least 4h. Elemental analysis studies revealed the actual integration of CM-beta-CD to CS nanoparticles. Insulin and heparin used as macromolecular model drugs, could be incorporated into the different nanocarriers with association efficiencies of 85.5-93.3 and 69.3-70.6%, respectively. The association of these compounds led to an increase of the size of the nanoparticles (366-613 nm), with no significant modification of their zeta potentials (+23.3 to +37.1 mV). The release profiles of the associated macromolecules were highly dependent on the type of molecule and its interaction with the nanomatrix: insulin was very fast released (84-97% insulin within 15 min) whereas heparin remained highly associated to the nanoparticles for several hours (8.3-9.1% heparin within 8h). In summary, CS-CD (cyclodextrin) nanoparticles may be considered as nanocarriers for the fast or slow delivery of macromolecules.
    [Abstract] [Full Text] [Related] [New Search]