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  • Title: Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.
    Author: Burgdorf S, Kautz A, Böhnert V, Knolle PA, Kurts C.
    Journal: Science; 2007 Apr 27; 316(5824):612-6. PubMed ID: 17463291.
    Abstract:
    The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8+ or CD4+ T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.
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