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  • Title: Synthesis and characterization of a new fluorescent probe for reactive oxygen species.
    Author: Heyne B, Beddie C, Scaiano JC.
    Journal: Org Biomol Chem; 2007 May 07; 5(9):1454-8. PubMed ID: 17464416.
    Abstract:
    We report the development of a new fluorescence sensor for reactive oxygen species (ROS) based on a benzofurazan structure. The sensor, NBFhd, is initially non-fluorescent and reacts with peroxyl radicals by hydrogen transfer in an aqueous medium under neutral conditions to release the fluorescent N-methyl-4-amino-7-nitrobenzofurazan (NBF) and 1,4-benzoquinone. NBFhd shows excellent contrast and no interference in the region of cell autofluorescence and is a new tool to detect ROS in homogeneous and biological systems.
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