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  • Title: Buprenorphine for pain relief in a patient with drug abuse.
    Author: Hughes JR, Bickel WK, Higgins ST.
    Journal: Am J Drug Alcohol Abuse; 1991; 17(4):451-5. PubMed ID: 1746507.
    Abstract:
    Buprenorphine is a mixed opioid agonist/antagonist which appears to produce less physical dependence and respiratory depression than typical mu-agonist opioids. These effects suggest its use for analgesia for drug abusers. However, buprenorphine may precipitate withdrawal from other opioids. The present case illustrates the utility of buprenorphine and describes a method to transfer a patient from a mu-agonist to buprenorphine without precipitating withdrawal or interrupting analgesia.
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