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  • Title: Validation of a Plasmodium falciparum parasite transformed with green fluorescent protein for antimalarial drug screening.
    Author: Sanchez BA, Varotti FP, Rodrigues FG, Carvalho LH.
    Journal: J Microbiol Methods; 2007 Jun; 69(3):518-22. PubMed ID: 17466399.
    Abstract:
    Aiming to replace the radioisotopic assay, the widely used procedure for vitro antimalarial drug screening, we set up a protocol using a Plasmodium falciparum strain transformed with the green fluorescent protein (PfGFP), which can be quickly and specifically quantified by flow cytometry. On the basis of a side-by-side comparison, this PfGFP-based method showed results similar to those obtained with the standard radioisotopic method.
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