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  • Title: Frequent occurrence of recombinants in mixed infections of tomato yellow leaf curl disease-associated begomoviruses.
    Author: García-Andrés S, Tomás DM, Sánchez-Campos S, Navas-Castillo J, Moriones E.
    Journal: Virology; 2007 Aug 15; 365(1):210-9. PubMed ID: 17467025.
    Abstract:
    Begomoviruses are plant DNA viruses for which recombination plays a key role in driving evolution. However, little is known about how frequently begomovirus recombinants arise in mixed infected plants. To tackle this issue, co-infections of tomato with monopartite begomoviruses associated with the tomato yellow leaf curl disease, Tomato yellow leaf curl Sardinia virus and Tomato yellow leaf curl virus, have been studied as a model system. The frequency of recombinant genotypes in the progeny populations was evaluated at several times post inoculation. Recombinants constituted a significant proportion of the viral population. Interestingly, not all regions of the genome contributed equally to genetic exchange. In addition to the intergenic region, a known hot spot for recombination, a second hot spot region was found. Implication of secondary structure sequence features in cross-over sites is suggested, which might favor discontinuous DNA replication with the replication complex switching between homologous regions of DNA templates.
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