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  • Title: Lipopolysaccharide in bacterial chronic infection: insights from Helicobacter pylori lipopolysaccharide and lipid A.
    Author: Moran AP.
    Journal: Int J Med Microbiol; 2007 Sep; 297(5):307-19. PubMed ID: 17467335.
    Abstract:
    Lipopolysaccharides are generally considered toxic components of the Gram-negative bacterial outer membrane with potent immunomodulating and immunostimulating properties, but their contribution to adaptation of a given bacterial species to its microbial niche is, however, predominantly overlooked. Helicobacter pylori, as a cause of long-term infection in the gastroduodenal tract, has been proposed as a model for investigating and understanding the dynamics of bacterial persistence and parasitism in chronic infections. This review examines the structure and properties of H. pylori lipopolysaccharide and its lipid A moiety, and the insights that have been gained into their contribution to chronic infection and pathogenesis, including evasion and dampening of innate immune responses.
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