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Title: Predictors of irritable bowel-type symptoms and healthcare-seeking behavior among adults with celiac disease.
Author: Häuser W, Musial F, Caspary WF, Stein J, Stallmach A.
Journal: Psychosom Med; 2007 May; 69(4):370-6. PubMed ID: 17470666.
Abstract:
OBJECTIVES: To assess the frequency of irritable bowel syndrome (IBS)-type symptoms and consecutive healthcare-seeking behavior, their impact on health-related quality of life (HRQOL), and their possible biopsychosocial determinants in adult patients with celiac disease (CD). METHODS: A total of 1000 adult patients with CD from the German Celiac Society completed a medical (including bowel) and a sociodemographic questionnaire, the Short Form Health Survey (SF-36), and the Hospital Anxiety and Depression Scale through a postal survey. RESULTS: Of 412 respondents with reported biopsy-proven diagnosis with major adherence to a gluten-free diet (GFD) for > or =1 year, 96 (23.3%) patients fulfilled the modified Rome I criteria for IBS. Of these 96 patients, 76 (79.2%) sought help (medical and/or nonmedical) due to bowel symptoms (referred to as patients with IBS). IBS-type symptoms had a significant negative impact on the physical summary score of the SF-36 (p = .05). Mental disorder (OR = 2.29; beta = 0.83; p = .006); female sex (OR = 2.34; beta = 0.85; p = .03), and occasional nonadherence to GFD (OR = 1.74; beta = 0.56; p = .05) were risk factors for IBS-type symptoms. Active medical comorbidities predicted IBS-patient status (OR = 0.40; beta = -0.92; p = .001). CONCLUSIONS: The data support the biopsychosocial model of IBS: IBS-type symptoms in adult patients with CD can be explained through an interaction of clinical and sociopsychological mechanisms.

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