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  • Title: Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours: discontinuation study.
    Author: Haessler F, Glaser T, Beneke M, Pap AF, Bodenschatz R, Reis O, Zuclopenthixol Disruptive Behaviour Study Group.
    Journal: Br J Psychiatry; 2007 May; 190():447-8. PubMed ID: 17470962.
    Abstract:
    We investigated the effects of zuclopenthixol on aggressive behaviour in patients with intellectual disabilities by randomly withdrawing it after a 6-week period of open treatment. Of the 49 patients responding to the treatment, 39 took part in a randomised withdrawal trial. The placebo subgroup (n=20) showed more aggressive behaviour as indicated by outcomes observed by external raters on the Modified Overt Aggression Scale than did the continuing subgroup (n=19). The results indicate that discontinuation of zuclopenthixolin this population leads to an increase in aggressive behaviour.
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