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  • Title: [Mechanism of beta(2)-microglobulin-related amyloid fibril formation in CKD].
    Author: Yamamoto S, Kazama JJ.
    Journal: Clin Calcium; 2007 May; 17(5):740-4. PubMed ID: 17471004.
    Abstract:
    Dialysis-related amyloidosis is a serious complication in patients on long-term dialysis. Amyloid fibrils, that major component is beta(2)-microglobulin (beta(2)-m) , deposit mainly in osteoarticular joint tissues and cause various complications such as carpal tunnel syndrome, destructive spondyloarthropathy, bone cysts, and various organ dysfunction. The retention of beta(2)-m in chronic kidney disease (CKD) induces the amyloid fibril formation according to a nucleation-dependent polymerization model. Specific molecules such as glycosaminoglycans and proteoglycans that affect the conformation and stability of beta(2)-m and amyloid fibrils are considered to have significant effects on the formation and deposition of amyloid fibrils.
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