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  • Title: AMPK mediates autophagy during myocardial ischemia in vivo.
    Author: Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T, Sadoshima J.
    Journal: Autophagy; 2007; 3(4):405-7. PubMed ID: 17471015.
    Abstract:
    We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.
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