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  • Title: [Narcolepsy: a new perspective on diagnosis and treatment].
    Author: Fronczek R, van der Zande WL, van Dijk JG, Overeem S, Lammers GJ.
    Journal: Ned Tijdschr Geneeskd; 2007 Apr 14; 151(15):856-61. PubMed ID: 17472116.
    Abstract:
    The 5 classic symptoms of narcolepsy are excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disturbed nocturnal sleep. The presence of cataplexy is strongly associated with a deficiency of the neuropeptide hypocretin. This discovery has led to new diagnostic subclassifications: narcolepsy without cataplexy, which can be demonstrated by a multiple sleep latency test, and narcolepsy with cataplexy, which can be confirmed with a multiple sleep latency test or a cerebrospinal fluid deficiency of hypocretin I. Various treatment options are available, including psychostimulants and gamma hydroxybuterate.
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