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  • Title: Radioprotective and antioxidant activity of fractionated extracts of berries of Hippophae rhamnoides.
    Author: Chawla R, Arora R, Singh S, Sagar RK, Sharma RK, Kumar R, Sharma A, Gupta ML, Singh S, Prasad J, Khan HA, Swaroop A, Sinha AK, Gupta AK, Tripathi RP, Ahuja PS.
    Journal: J Med Food; 2007 Mar; 10(1):101-9. PubMed ID: 17472473.
    Abstract:
    Plants are an abundant source of medicinal compounds, some of which are useful in combating free radical-mediated oxidative stress. In the present study, initially two fractions designated REC-1001 (flavonoid-rich fraction) and REC-1002 (flavonoid-poor fraction) of Hippophae rhamnoides were screened on the basis of their reducing power in the aqueous phase. REC-1001 was selected for further study, since it exhibited 27.38 times higher antioxidant activity than REC-1002. REC-1001 also showed significant (P < .05) membrane protection potential at 50 microg/mL, which was attributed to its ability to scavenge peroxyl radicals (64.82 +/- 1.25% scavenging within 1,440 min). A significant (P < .05) difference of 67.02% in free radical scavenging activity at 1,000 ng/mL between REC-1001 and vitamin E demonstrated the extract fraction's worth in radiation protection. Such activities were attributed to the presence of quercetin, isorhamnetin, and kaempferol in this fraction. Further, REC-1001 was found to be nontoxic up to 200 mg/kg of body weight. This research suggests that the REC-1001 fraction of H. rhamnoides extract is a safe and effective antioxidant nutraceutical product.
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