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  • Title: [Fibrates and markers of inflammation].
    Author: Broncel M.
    Journal: Pol Merkur Lekarski; 2007 Jan; 22(127):58-61. PubMed ID: 17477093.
    Abstract:
    Inflammatory processes have important roles in the etiology of atherosclerosis. Several studies have shown that elevated plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adhesions molecules, monocyte chemoattractant protein-1 (MCP-1) are associated with the risk of coronary heart disease. Fibrates, agonists of peroxisome proliferator-activated receptors alpha (PPARalpha), act to modulate the expression of key genes of lipid transport and metabolism in the liver and adipose tissue. Besides the hipolipemic effects they exert pleiotropic, anti-inflammatory properties downregulating expression of genes encoding acute phase proteins and inflammatory cytokines. In this article, we briefly review the clinical trial data on the effects of fibrates on the inflammatory markers.
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