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  • Title: Diabetes mellitus in sand rats (Psammomys obesus): microangiopathy during development of the diabetic syndrome.
    Author: Marquie G, Duhault J, Hadjiisky P, Petkov P, Bouissou H.
    Journal: Cell Mol Biol; 1991; 37(6):651-67. PubMed ID: 1747900.
    Abstract:
    The purpose of the study was to investigate the development of microangiopathic complications in North African sand rats with diabetes induced by a long-term standard laboratory diet. Hyperinsulinaemic rats, whether non-diabetic obese or diabetic, developed capillary basement membrane (CBM) thickening in the skin; in insulin-dependent animals, this change was diffuse. Many PAS positive areas were demonstrated in skeletal muscle and myocardium, together with evidence of microangiopathy; the primary myocardial lesion in insulin-dependent disease was ischaemic fibrosis. The kidney was also affected with marked basement membrane thickening in Bowman's capsule and glomerular capillaries; glomerulosclerosis and tubular changes were found in insulin-dependent disease. No evidence of diabetic retinopathy was found, and there was a high incidence of cataract.
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