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  • Title: Anti-babesial compounds from Curcuma xanthorrhiza.
    Author: Matsuura H, Nomura S, Subeki, Yamada K, Yamasaki M, Yamato O, Maede Y, Katakura K, Trimurningsih, Chairul, Yoshihara T, Nabeta K.
    Journal: Nat Prod Res; 2007 Apr; 21(4):328-33. PubMed ID: 17479421.
    Abstract:
    Anti-babesial ingredients, (12R)- and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizols, were isolated from Curcuma xanthorrhiza. The structures were established by the extensive NMR techniques. The assignments of (1)H NMR data of (12R)-12,13-dihydro-12,13-dihydroxyxanthorrhizol was revised, and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizol was isolated as a pure form for the first time. The IC(50) of the active compounds were compared with that of commercial drug, diminazene aceturate (Ganaseg). IC(50) values of Ganaseg, (12R)-, and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizols were 0.6 microg mL(-1), 8.3 microg mL(-1) and 11.6 microg mL(-1), respectively.
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