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  • Title: Short synthesis and antiviral evaluation of C-fluoro-branched cyclopropyl nucleosides.
    Author: Oh CH, Hong JH.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2007; 26(4):403-11. PubMed ID: 17479435.
    Abstract:
    A series of novel fluorocyclopropyl nucleosides were synthesized using the Simmons-Smith reaction as a key reaction starting from 1,3-dihydroxyacetone. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the 5-fluorouracil analogue 15 showed significant anti-HCMV activity (9.22 microM).
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