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  • Title: Autoantibodies against Forssman glycolipids in Graves' disease and Hashimoto's thyroiditis.
    Author: Ariga T, Yoshida T, Mimori T, Yu RK.
    Journal: Clin Exp Immunol; 1991 Dec; 86(3):483-8. PubMed ID: 1747956.
    Abstract:
    Sera from patients with Graves' disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin-layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves' disease. A MoAb, TRMo-4, reacted strongly and specifically with Gb5. These results suggest that anti-Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti-Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.
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