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  • Title: Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine.
    Author: Tsuchihashi T, Tsukashima A, Matsumura K, Abe I, Tominaga M, Nakao Y, Kobayashi K, Fujishima M.
    Journal: Eur J Clin Pharmacol; 1991; 41(3):255-7. PubMed ID: 1748143.
    Abstract:
    A newly developed calcium antagonist, nilvadipine, was administered to 7 hypertensive patients aged 75.6 y. Nilvadipine 4 mg b.d. decreased the average 24-h blood pressure significantly from 169/89 mmHg to 152/81 mmHg after 7 to 14 days without any change in the pulse rate. The circadian patterns of blood pressure and pulse rate were not affected by nilvadipine. Although the present study was a preliminary one done over a short period in a small number of patients, the results suggest that nilvadipine exerts an antihypertensive effect without altering the circadian pattern or the variability of blood pressure in elderly hypertensive patients.
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