These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Identification of thymocyte precursors in murine fetal liver.
    Author: Bell SE, Zamoyska R.
    Journal: Eur J Immunol; 1991 Dec; 21(12):2931-6. PubMed ID: 1748146.
    Abstract:
    We have isolated thymic stem cells from murine fetal liver using a combination of approaches including discontinuous albumin density gradient separation and anti-heat-stable antigen (HSA) antibody plus complement-mediated lysis. A population of early precursors has been identified which comprises approximately 1% of fetal liver, and which has the capacity to reconstitute alymphoid lobes and give rise to the four thymic subpopulations defined by expression of the T cell differentiation antigens CD4 and CD8. These early precursors express CD44 (Pgp-1), however, they are negative for expression of Thy-1, CD4, CD8, CD3, membrane immunoglobulin and HSA cell surface molecules.
    [Abstract] [Full Text] [Related] [New Search]