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  • Title: Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.
    Author: Schulte-Mattler WJ, Opatz O, Blersch W, May A, Bigalke H, Wohlfahrt K.
    Journal: J Neurol Sci; 2007 Sep 15; 260(1-2):38-42. PubMed ID: 17481662.
    Abstract:
    A genuine peripheral antinociceptive and anti-inflammatory effect of Botulinum neurotoxin type A (BoNT/A) has been proposed but could not be demonstrated in humans so far. Therefore, 100 mouse units of Botulinum toxin A (Dysport) and placebo were injected in a double blind paradigm in defined skin areas of 50 subjects. At baseline and after 4 and 8 weeks allodynia was induced in the skin areas with capsaicin ointment. Heat and cold pain threshold temperatures were measured with quantitative sensory testing, and threshold intensities upon electrical stimulation with a pain specific surface electrode were determined. No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans.
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