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  • Title: Diagnosis of Mullerian anomalies in adults: evaluation of practice.
    Author: Mazouni C, Girard G, Deter R, Haumonte JB, Blanc B, Bretelle F.
    Journal: Fertil Steril; 2008 Jan; 89(1):219-22. PubMed ID: 17482176.
    Abstract:
    OBJECTIVE: To evaluate the circumstances associated with the diagnosis of Mullerian anomalies in adults. DESIGN: Retrospective observational study. SETTING: University hospital. PATIENT(S): All patients with Mullerian anomalies referred for evaluation. INTERVENTION(S): All patients underwent radiologic and operative diagnostic workup using ultrasonography, or ultrasonography and hysteroscopy, and in some cases laparoscopy. MAIN OUTCOME MEASURE(S): Clinical symptoms and radiologic investigations leading to the diagnosis. Mode and number of investigations before the diagnosis, and the time since the initial symptoms to the final diagnosis. RESULT(S): One hundred ten patients were diagnosed with Mullerian anomalies: 73 septate uteri, 20 bicornuate uteri, 10 uterine hypoplasia, 4 unicornuate uteri, and 3 with Mayer- Mayer-Rokitansy-Küster-Hauser syndrome. The circumstances leading to the diagnosis were infertility (33.6%), repeat miscarriage (18.2%), ultrasonography during pregnancy (12.7%), pregnancy complications during last trimester (11%), abnormal examination (8.2%), and miscellaneous causes (16.3%). Up 50% of patients complained of gynecologic signs before the appropriate diagnosis. Radiologic diagnosis required two complementary imaging techniques in 62% of patients and more than two in 28%. The correct diagnosis was established in only 40% of cases before hospitalization. Most of the anomalies were initially diagnosed at hysterosalpingography and ultrasonography. The mean time between the first imaging examination and the diagnosis in a specialized department was 6.7 (+/-7.1) months. CONCLUSION(S): The diagnosis of Mullerian anomalies in adults is often made at the time of conception and obstetric complications. There is a tendency toward the use of multiple imaging techniques and this delayed the diagnosis.
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