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  • Title: Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs.
    Author: Olivero DK, Davidson MG, English RV, Nasisse MP, Jamieson VE, Gerig TM.
    Journal: J Am Vet Med Assoc; 1991 Oct 15; 199(8):1039-42. PubMed ID: 1748606.
    Abstract:
    Keratoconjunctivitis sicca (KCS) is a prevalent and often vision-threatening condition in dogs. In several reports, 2% cyclosporine (cyclosporin A, CsA) was described as effective in modulating the clinical signs of KCS. This study was designed to compare the efficacy of 1% CsA vs a placebo, using a randomized double-blind clinical trial. Topical administration of 1% CsA significantly improved Schirmer wetting values and subjective markers of corneal health as compared with the placebo. In the dogs treated with topical administration of 1% CsA, the clinical signs of KCS were improved in 81.8% of cases.
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